Optical Imaging Laboratory
Optical technologies are attractive for diagnosing cancer and for monitoring cancer therapy because these techniques are inexpensive, portable, fast and provide a wealth of information on tissue structure and function. Dr. Skala's lab focuses on the development of optical imaging tools that monitor biological markers such as cellular metabolic rate, molecular expression, blood oxygenation and blood flow. These tools are applied to pre-clinical models for the design and development of effective therapeutic strategies, and in clinical studies to provide early detection and individualized treatment to cancer patients. Specific technologies under development include optical coherence tomography to monitor blood flow and microvessel morphology, multiphoton and fluorescence lifetime microscopy to image cellular metabolism, photothermal microscopy with nanoparticle contrast agents for molecular imaging, and optical spectroscopy to quantify tissue blood content and oxygenation.
Where to find us:
Optical Society of America: Optics in Life Sciences Congress , 14-18 April, Kona, Hawaii[MT3C.3] April 16, 2013 from 11:45AM to 12:00 PM
"A Novel Optical Metabolic Assay of Cancer Drug Efficacy in Primary 3D Tumor Cultures."
A. Walsh, R.S. Cook, C.L. Arteaga, M.C. Skala
[MT3C.5] April 16, 2013 from 12:15PM to 12:30 PM
"Autofluorescence Imaging Resolves Early Cancer Treatment Response In Vivo."
A. Walsh, R.S. Cook, H.C. Manning, D.J. Hicks, A. Lafontant, C.L. Arteaga, M.C. Skala
[MTh2B.4] April 18, 2013 from 10:15 AM to 12:15 PM
"Full Range Photothermal Optical Coherence Tomography of Gold Nanoparticles."
J.M. Tucker - Schwartz; M.J. Schultis; K. Beavers; C. Duvall; M.C. Skala
NSF Workshop on US-Czech Frontiers in Photonics, 18-19 April, Prague, Czech Republic
"Optical Metabolic Imaging of Treatment Response in Head and Neck Cancer."
A. Shah, M. Demory Beckler, A. Walsh, P. Pohlmann, M.C. Skala
Advances in Optics for Biotechnology, Medicine and Surgery XIII, 2-5 June, Lake Tahoe, California
"Optical Imaging of Vascular Remodeling and Blood Oxygenation After Growth Factor Treatment in the Mouse Hind Limb Ischemia Model."
K.M. Poole, J.M. Tucker-Schwartz, C.A. Patil, C.E. Nelson, C.L. Duvall, M.C. Skala
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