Mechanistic Studies of Optical Nerve Stimulation
Research is being performed to identify the mechanism of optical
nerve stimulation. This
research includes laser, thermal, and biological studies of the
mechanism on various nerves.
Different laser wavelengths, pulse durations, and energies
are being identified for their success in optical nerve stimulation.
Once the appropriate pulse energies are determined for
specific pulse durations and wavelengths, the temperature change of
the nerve during its optical stimulation is being identified using a
FLIR thermal camera. In
addition, biological studies of the ion channels of the peripheral
rat nerve and aplysia
californica are being analyzed during optical nerve stimulation
through fluorescent imaging to help determine what biological
interactions are involved with optical nerve stimulation beyond the
simple thermal changes of neurons.
Duke AR, Gault MA, Eckert J, Lu H, Jenkins MW, Chiel HJ, Jansen ED –
Investigating the effects of infrared neural stimulation in the
Aplysia californica – SPIE Photonics West, San Francisco CA, 2010.
Eckert J, Gault MA, Duke AJ, Jenkins
MW, Lu H, Jansen ED, Rollins AM, Chiel HJ
– Investigating optical methods for imaging and stimulating neurons
– ShowCASE, Case Western University Symposium, Cleveland, OH