VUSEVU Biomedical Photonics

Infrared Neural Stimulation for the Central Nervous System

Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS.  The current studies designed to optimize INS for in vivo stimulation of CNS structures is focused on stimulating the cortex of the cerebrum and cerebellum.  We have shown that infrared light activates cortex using both optical imaging and electrophysiological techniques.  The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural interface machines.


References

J. M. Cayce, R. M. Friedman, G. Chen, E. D. Jansen, A. Mahadevan-Jansen, and A. W. Roe, "Infrared neural stimulation of primary visual cortex in non-human primates," Neuroimage, vol. 84C, pp. 181-190, Aug 28 2013.

J. M. Cayce, R. Friedman, E. Jansen, A. Mahadevan-Jansen, and A. Roe, "Functional characterization of infrared neural stimulation in non-human primate cortex," in SPIE Photonics West, San Francisco, 2012, pp. 8207G-149.

J. M. Cayce, R. M. Friedman, E. D. Jansen, A. Mahavaden-Jansen, and A. W. Roe, "Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo," Neuroimage, vol. 57, pp. 155-66, Jul 1 2011.

A. Mahadevan-Jansen, J. M. Cayce, R. Friedman, A. W. Roe, P. E. Konrad, E. Hillman, and E. Jansen, "Imaging optically induced neural activity in the brain," Conf Proc IEEE Eng Med Biol Soc, vol. 2010, pp. 3379-81, 2010.

Cayce JM, Kao CC, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A, Optical stimulation of thalamocortical brain slices, IEEE J Spec Topics Quantum Electr 16(3): 565-72 (2010).

Cayce JM, Friedman R, Roe A, Jansen ED, Konrad PE, Mahadevan-Jansen A, Infrared Neural Stimulation and Optical Recording of Somatosensory Cortex, In: Photons and Neurons, BiOS 2009, Photonics West, San Jose CA, January 2009.

Cayce JM, Friedman RM, Roe AW, Jansen ED, Konrad PE, Mahadevan-Jansen A - Infrared neural stimulation and optical recording of somatosensory cortex. - SPIE Photonics West San Jose, CA (2009).

Cayce JM, Friedman RM, Remple M, Konrad PE, Jansen ED, Mahadevan-Jansen A, Roe AW. Infrared neural stimulation of the somatosensory cortex of the rat. Society for Neuroscience 2008. Washington DC.

Cayce JM, Kao CC, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A Optical Stimulation of the Central Nervous System in vitro OSA Topical meeting Biomed, St. Petersburg, FL, March 2008.

Cayce J, Kao CC, Mahadevan G, Malphrus J, Konrad PE, Mahadevan-Jansen A, Jansen ED Optical Stimulation of Rat Thalamocortical Brain Slices in: Optical interactions with cells and tissues XIX SPIE, San Jose, CA (2008).

Kao CC, Cayce JM, Jansen ED, Mahadevan-Jansen A, Konrad PE Optical evoked high-frequency following action potentials in rat thalamocortical slices (136.1) - Society for neuroscience Annual meeting, Washington DC, November (2008)

Kao C, Cayce JM, Janesn ED, Mahadevan-Jansen A, Konrad PE. Optical evoked high-frequency following action potentials in rat thalamocortical slices. Society for Neuroscience 2008. Washington DC.


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