Infrared Neural Stimulation for the Central Nervous System
Infrared neural stimulation (INS) is well characterized for the
peripheral nervous system; however, translation to the central
nervous system (CNS) presents a new set of challenges which require
us to consider different anatomy, multiple cell types, and the
physiology associated with structures in the CNS.
The current studies designed to optimize INS for
in vivo stimulation of CNS
structures is focused on stimulating the cortex of the cerebrum and
cerebellum. We have
shown that infrared light activates cortex using both optical
imaging and electrophysiological techniques.
The implications of this work could lead to neural implants
which allows for single cell stimulation making it possible to
design closed loop neural interface machines.
J. M. Cayce, R. M. Friedman, G. Chen, E. D. Jansen, A. Mahadevan-Jansen, and A. W. Roe, "Infrared neural stimulation of primary visual cortex in non-human primates," Neuroimage, vol. 84C, pp. 181-190, Aug 28 2013.
J. M. Cayce, R. Friedman, E. Jansen, A. Mahadevan-Jansen, and A. Roe, "Functional characterization of infrared neural stimulation in non-human primate cortex," in SPIE Photonics West, San Francisco, 2012, pp. 8207G-149.
J. M. Cayce, R. M. Friedman, E. D. Jansen, A. Mahavaden-Jansen, and A. W. Roe, "Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo," Neuroimage, vol. 57, pp. 155-66, Jul 1 2011.
A. Mahadevan-Jansen, J. M. Cayce, R. Friedman, A. W. Roe, P. E. Konrad, E. Hillman, and E. Jansen, "Imaging optically induced neural activity in the brain," Conf Proc IEEE Eng Med Biol Soc, vol. 2010, pp. 3379-81, 2010.
Cayce JM, Kao CC, Malphrus JD, Konrad PE, Jansen ED, Mahadevan-Jansen A, Optical
stimulation of thalamocortical brain slices,
IEEE J Spec Topics Quantum Electr 16(3): 565-72 (2010).
Cayce JM, Friedman R, Roe A, Jansen ED, Konrad PE, Mahadevan-Jansen
A, Infrared Neural Stimulation and Optical Recording of
Somatosensory Cortex, In:
Photons and Neurons, BiOS
2009, Photonics West, San Jose CA, January 2009.
Cayce JM, Friedman RM, Roe AW, Jansen ED, Konrad PE,
Mahadevan-Jansen A - Infrared neural stimulation and optical
recording of somatosensory cortex. - SPIE Photonics West San Jose,
Cayce JM, Friedman RM, Remple M, Konrad PE, Jansen ED,
Mahadevan-Jansen A, Roe AW. Infrared neural stimulation of the somatosensory cortex of
the rat. Society for
Neuroscience 2008. Washington DC.
Cayce JM, Kao CC, Malphrus JD, Konrad PE,
Jansen ED, Mahadevan-Jansen A –
Optical Stimulation of the Central Nervous System in vitro – OSA
Topical meeting Biomed, St. Petersburg, FL, March 2008.
Cayce J, Kao CC, Mahadevan G, Malphrus J, Konrad PE,
Mahadevan-Jansen A, Jansen ED –
Optical Stimulation of Rat
Thalamocortical Brain Slices – in:
Optical interactions with cells and tissues XIX – SPIE, San Jose, CA
Kao CC, Cayce JM, Jansen ED, Mahadevan-Jansen A, Konrad PE –
evoked high-frequency following action potentials in rat
thalamocortical slices (136.1) - Society for neuroscience Annual
meeting, Washington DC, November (2008)
Kao C, Cayce JM, Janesn
ED, Mahadevan-Jansen A, Konrad PE.
Optical evoked high-frequency following action potentials in
rat thalamocortical slices.
Society for Neuroscience 2008.