Infrared neural stimulation (INS) is well characterized for the peripheral nervous system; however, translation to the central nervous system (CNS) presents a new set of challenges which require us to consider different anatomy, multiple cell types, and the physiology associated with structures in the CNS.  The current studies designed to optimize INS for in vivo stimulation of CNS structures is focused on stimulating the cortex of the cerebrum and cerebellum.  We have shown that infrared light activates cortex using both optical imaging and electrophysiological techniques.  The implications of this work could lead to neural implants which allows for single cell stimulation making it possible to design closed loop neural interface machines.

References

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J. M. Cayce, R. Friedman, E. Jansen, A. Mahadevan-Jansen, and A. Roe, "Functional characterization of infrared neural stimulation in non-human primate cortex," in SPIE Photonics West, San Francisco, 2012, pp. 8207G-149.

J. M. Cayce, R. M. Friedman, E. D. Jansen, A. Mahavaden-Jansen, and A. W. Roe, "Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo," Neuroimage, vol. 57, pp. 155-66, Jul 1 2011.

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