VUSEVU Biomedical Photonics

 Peer Reviewed Journal Articles


AT Shah, M Demory Beckler, AJ Walsh, WP Jones, PR Pohlmann, and MC Skala. “Optical Metabolic Imaging of Treatment Response in Human Head and Neck Squamous Cell Carcinoma.” PLOS ONE (2014) accepted.

A Venkateswaran, KR Sekhar, DS Levic, DB Melville, TA Clark, WM Rybski, AJ Walsh, MC Skala, PA Crooks, EW Knapik, and ML Freeman. “The NADH Oxidase ENOX1, a Critical Mediator of Endothelial Cell Radiosensitivity, is Crucial for Vascular Development.” Cancer Research (2014) Jan 1;74(1):38-43.

Cayce JM, Friedman RM, Chen G, Jansen ED, Mahadevan-Jansen A, Roe AW (2014). Infrared neural stimulation of primary visual cortex in non-human primates. Neuroimage 84, 181 – 190 (2014).

Patil CA, Pence IJ, Lieber CA, Mahadevan-Jansen A 1064 nm dispersive Raman spectroscopy of tissues with strong near-infrared autofluorescence, Applied Optics, 39: (2), (2014)

Bi X, Rexer B, Arteaga CA, Guo M, Mahadevan-Jansen A, Evaluating HER2 Amplification Status and Acquired Drug Resistance in Breast Cancer Cells Using Raman Spectroscopy. Journal of Biomedical Optics,DOI: 10.1117/1.JBO.19.2.025001, 19(2), 025001 February 2014.

Cayce JM, Bouchard M, Chen B, Jansen ED, Hillman EM, and Mahadevan-Jansen A, Optical characterization of rodent brain activity with infrared neural stimulation, Cell Calcium (in press), (2014)

Cayce JM, Wells JD, Malphrus JD, Kao C, Thomsen, S, Tulipan NB, Konrad PE, Jansen ED, and Mahadevan-Jansen A. "Infrared neural stimulation of human spinal nerve roots". Neurosurgery (in review), 2014.

O’Brien CM, Vargis E, Paria BC, Bennett KA, Mahadevan-Jansen A, Reese J – Raman Spectroscopy as a non-invasive approach to determine biochemical composition of the pregnant cervix in vivo – Acta Paediatrica (in review), 2014

Vargis E, Byrd T, O’Brien C, Logan Q, Khabele D, Mahadevan-Jansen A, Classifying cervical dysplasia with Raman spectroscopy, Gynecologic Oncology, (in review), (2014).

Caldwell B, Pence IJ, Nguyen TQ, Krishnamoorthi H, Stone N, Mahadevan-Jansen A, Calibration across Raman systems for clinical applications, Journal of Biomedical Optics, (in review), 2014


Cayce JM, Friedman RM, Chen G, Jansen ED, Mahadevan-Jansen A, Roe AW - Infrared neural stimulation of primary visual cortex in non-human primates -  NeuroImage, 84: 181-190 (2013)

Pence IJ, Vargis E, Mahadevan-Jansen A, Assessing variability of in vivo tissue Raman spectra, Applied Spectroscopy, 67(7), 789-800, (2013).

Duke AR, Jenkins M, Lu H, McManus JM, Chiel HJ, Jansen ED - Reversible and selective inhibition of neural activity with infrared light – Scientific Reports 3:2600 (2013). DOI: 10.1038/srep02600

Bi, X, Sterling, JA, Merkel, AR, Perrien, DS, Nyman, JS, Mahadevan-Jansen A. Prostate Cancer Metastases Alter Bone Mineral and Matrix Composition Independent of Effects on Bone Architecture in Mice - A Quantitative Study Using microCT and Raman Spectroscopy. Bone. 56(2):454-460, (2013).

McWade MA, Paras C, White LM, Phay JE, Mahadevan-Jansen A, Broome JT. A novel approach to intraoperative detection of parathyroid glands. Surgery 154(6):1371-1377 (2013)

Makowski, A.J., Patil, C.A., Mahadevan-Jansen, A., and J.S. Nyman. Polarization Control of Raman Spectroscopy Optimizes the Assessment of Bone Tissue. Journal of Biomedical Optics. 18(5), Article number 055005, (2013).

A Venkateswaran, DB Friedman, AJ Walsh, MC Skala, S Sasi, G Rachakonda, PA Crooks, ML Freeman, and KR Sekhar. The novel antiangiogenic VJ115 inhibits the NADH oxidase ENOX1 and cytoskeleton-remodeling proteins. Invest New Drugs (2013). Jun;31(3):535-44.  PMID: 23054211

RV Joshi, CE Nelson, KM Poole, MC Skala, and CL Duvall. Dual pH- and Temperature-responsive Microparticles for Protein Delivery to Ischemic Tissues.  Acta Biomaterialia (2013) May;9(5):6526-34.  PMID: 23402764

JR Trantum, ZE Eagleton, CA Patil, JM Tucker-Schwartz, ML Baglia, MC Skala, FR Haselton.  Cross-Sectional Tracking of Particle Motion in Evaporating Drops: Flow Fields and Interfacial Accumulation.  Langmuir (2013). May 28;29(21):6221-31.  PMID: 23611508

MC Skala, MJ Crow, A Wax, JA Izatt.  Three-dimensional molecular imaging with photothermal optical coherence tomography. Methods Mol Biol (2013).1026:85-92. PMID: 23749571.

KM Poole, JM Tucker-Schwartz, W Sit, AJ Walsh, CL Duvall, MC Skala. “Quantitative, Intravital Optical Imaging of Vascular Response in vivo in a Preclinical Model of Peripheral Arterial Disease.”  Am J Physiol-Heart C (2013). Oct;305(8):H1168-H1180. PMID: 23955718

AJ Walsh, RS Cook, HC Manning, DJ Hicks, A Lafontant, CL Arteaga, and MC Skala.  “Optical metabolic imaging identifies breast cancer glycolytic levels, sub-types, and early treatment response.”  Cancer Research (2013). Oct 15;73(20):6164-6174. PMID: 24130112

Gault MA, Mackanos MA, Duke AR, Chiel HJ, Jansen ED - Laser parameter optimization for infrared nerve stimulation in the peripheral nerve - J Neuroscience Methods (in review) (2013).

Chernov M, Cayce JM, Louw S, Frens MA, Jansen ED - Application and  mechanisms of infrared nerve stimulation in cerebellum - J Neural Engineering (in review) (2013).

Cayce JM, Wells JD, Malphrus JD, Kao C, Thomsen, S, Tulipan NB, Konrad PE, Jansen ED, Mahadevan-Jansen A - Infrared neural stimulation of human spinal nerve roots". J of Neurosurgery (in review).

Cayce JM, Bouchard MB, Chernov MM, Chen BR, Grosberg LE, Jansen ED, Hillman E, Mahadevan-Jansen A - Calcium imaging of infrared-stimulated activity in rodent brain - Cell Calcium (in press).


Vargis E, Brown N, Williams KC, Paria BC, Al-Hendy A, Reese J, Mahadevan-Jansen A, Detecting biochemical changes that occur in the rodent cervix during pregnancy, Annals of Biomedical Engineering, 40: (8), 1814-1824, (2012).

JM Tucker-Schwartz, TA Meyer, CA Patil, CL Duvall, and MC Skala. In vivo photothermal optical coherence tomography of gold nanorod contrast agents. Biomed Opt Express (2012). 3(11):2881-2895.  PMID: 23162726

Makowski AJ, Davidson JM, Mahadevan-Jansen A, Jansen ED - In vivo analysis of laser preconditioning in incisional wound healing of wild-type and HSP70 knockout mice with Raman spectroscopy  -  Lasers Surg Med 44(3): 233-44 (2012)   DOI: 10.1002/lsm.22002

A Walsh, RS Cook, B Rexer, CL Arteaga, and MC Skala. "Optical imaging of metabolism in HER2 overexpressing breast cancer cells," Biomed. Opt. Express (2012). 3, 75-85.  PMID: 22254170

JM Tucker-Schwartz, T Hong, DC Colvin, Y Xu, and MC Skala.  Dual Modality Photothermal Optical Coherence Tomography and Magnetic Resonance Imaging of Carbon Nanotubes.  Opt. Lett. (2012). 37, 872-874. PMID: 22378422

Mackanos MA, Simanovskii DM, Contag CH, Kozub JA, Jansen ED - Comparing an optical parametric oscillator (OPO) as a viable alternative for mid-infrared  tissue ablation with a free electron laser (FEL) - Lasers in Medical Science 27(6): 1213-23 (2012).   DOI: 10.1007/s10103-011-1048-1

AJ Walsh, KM Pool, CL Duvall, and MC Skala.  Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status.  J. Biomed. Opt. (2012). 17(11), 116015.  PMID: 23117810.

Patil CA, Arrasmith C, Mackanos MA, Dickensheets DA, and Mahadevan-Jansen A, A handheld laser scanning confocal reflectance imaging – confocal Raman microspectroscopy probe, Biomedical Optics Express, 3(3), 488-502, (2012).

AJ Walsh, KM Pool, CL Duvall, and MC Skala.  Ex vivo optical metabolic measurements from cultured tissue reflect in vivo tissue status.  J. Biomed. Opt. (2012). 17(11), 116015.  PMID: 23117810.

Mackanos MA, Simanovskii DM, Schriver KE, Hutson MS, Contag CH, Kozub JA, Jansen ED - Pulse duration dependent mid-infrared laser ablation for biological applications – IEEE Journal of Selected Topics in Quantum Electronics 18(4): 1514-22  (2012).   DOI: 10.1109/JSTQE.2012.2188501

Vargis E, Tang YW, Khabele D, Mahadevan-Jansen A, Near-infrared Raman microspectroscopy detects high-risk strains of human papillomavirus, Translational Oncology, 5(3), 172-179, (2012)

Chernov MM, Duke AR, Cayce JM, Crowder SW, Sung HJ, Jansen ED - Material considerations for optical interfacing to the nervous system - MRS Bulletin 37(6):599-605 (2012)   DOI: 10.1557/mrs.2012.121

Duke AR, Lu H, Jenkins MW, Chiel HJ, Jansen ED - Spatial and temporal variability in response to hybrid electro-optical stimulation - Journal of Neural Engineering 9(3)  (2012)   DOI: 10.1088/1741-2560/9/3/036003

Walsh A, Masters DB, Jansen ED, Welch AJ, Mahadevan-Jansen A -  The effect of temperature on the autofluorescence of scattering and non-scattering tissue  - Laser Surg Med 44(9): 712-8 (2012).   DOI: 10.1002/lsm.22080

Duke AR, Peterson E, Mackanos MA, Atkinson J, Tyler D, Jansen ED - Hybrid electro-optical stimulation of the rat sciatic nerve induces force generation in the plantarflexor muscles - Journal of Neural Engineering 9(6) (2012).   DOI: 10.1088/1741-2560/9/6/066006


Beckham JT, Wilmink GJ, Opalenik SR, Mackanos MA, Abraham AA, Takahashi K, Contag CH, Takahashi T, Jansen ED – Microarray analysis of cellular thermotolerance – Lasers Surg Med 42(10): 753-65 (2011).

Richter CP, Matic AI, Wells J, Jansen ED, Walsh JT - Neural stimulation with optical radiation – Laser Photonic Rev 5(1): 68-80 / DOI 10.1002/lpor.200900044 (2011).

Cayce J, Friedman R, Jansen ED, Mahadevan-Jansen A, Roe A – Pulsed infrared light alters neural activity in rat somatosensory cortex in vivo – NeuroImage 57, 155-166 (2011).

Bi X, Patil CA, Lynch CC, Pharr GM, Mahadevan-Jansen A, Nyman JS, Raman and mechanical properties correlate at whole bone and tissue levels in a genetic mouse model, Journal of Biomechanics, 44(2), 297-303, DOI: 10.1016/j.jbiomech.2010.10.009, 2011.

Bi X, Walsh A, Mahadevan-Jansen A, Herline A, Development of spectral markers for the discrimination of ulcerative colitis and Crohn’s disease using Raman spectroscopy, Disease of the Colon and Rectum, 54(1), 48-53, 2011.

Nyman JS, Lynch CC, Perrien DS, Thiolloy S, O’Quinn EC, Patil CA, Bi X, Pharr GM, Mahadevan-Jansen A, Mundy GR, Differential effects between the loss of MMP-2 and MMP-9 on structural and tissue-level properties of bone, Journal of Bone Mineral Research, 26(6): 1252-1260, DOI: 10.1002/jbmr.326 (2011).

Keller MD, Vargis E, Granja ND, Wilson RH, Mycek MA, Kelley MC, Mahadevan-Jansen A, Development of a spatially offset Raman spectroscopy probe for breast tumor surgical margin evaluation, Journal of Biomedical Optics 16(7), 077006 doi:10.1117/1.3600708, 2011.

Patil CA, Krishnamoorthi H, Ellis DL, Van Leeuwen T, Mahadevan-Jansen A, A clinical instrument for combined Raman Spectroscopy-Optical Coherence Tomography of skin cancers, Lasers in Surgery and Medicine, 43(2): 143-151 (2011). doi: 10.1002/lsm.21041.

Patil CA, Kalkman J, Faber DJ, Nyman JS, Van Leeuwen T, Mahadevan-Jansen A, Integrated system for combined Raman Spectroscopy-Spectral Domain Optical Coherence Tomography, Journal of Biomedical Optics 16(1): 011007-1 – 011007-10 (2011).

Zaman R, Rajaram N; Walsh A, Oliver J, Rylander H, Tunnell J, Welch AJ, Mahadevan-Jansen A, Variation of fluorescence in tissue with temperature, Lasers in Surgery and Medicine, 43(1), 36-42, (2011).

Paras C, Keller MD, White L, Phay J, Mahadevan-Jansen A, Near-Infrared Autofluorescence for the Detection of Parathyroid Glands, Journal of Biomedical Optics 16(6), #067012, DOI: 10.1117/1.3583571, (2011).

Vargis E*, Kanter EM*, Majumder S, Beaven RB, Rao GG, Mahadevan-Jansen A, Effect of normal variations on classification of Raman spectra of cervical tissue, The Analyst, 136(14): 2981-2981 (2011).

Nyman JS, Masui TP, Patil CA, Bi X, O’Quinn EC, Guelcher SA, Nicollela DP, Mahadevan-Jansen A, Measuring differences in compositional properties of bone tissue by confocal Raman spectroscopy”, Calcified Tissue International 89(2): 111-122, DOI: 10.1007/s00223-011-9497-x, (2011).


Cayce JM, Kao CC, Malphrus JD, Konrad PE, Mahadevan-Jansen A, Jansen ED – Infrared Neural Stimulation of Thalamocortical Brain Slices – IEEE J Spec Topics Quantum Electr 16(3): 565-72 (2010).

Feng HJ, Kao CC, Gallagher MJ, Jansen ED, Mahadevan-Jansen A, Konrad PE, MacDonald RL – Alteration of GABAergic neurotransmission by pulsed infrared laser stimulation – J Neurosci Meth, 192(1), 110-114 (2010).

Jenkins MW, Duke AR, Gu S, Chiel HJ, Watanabe M, Jansen ED, Rollins AM – Optical pacing of the embryonic heart – Nature Photonics, Aug 15, doi:10.1038/nphoton.2010.166 (2010).

Edwards JR, Nyman JS, Lwin ST, Moore MM, Esparza J, O’Quinn EC, Hart AJ, Biswas S, Patil CA, Lonning S, Mahadevan-Jansen A, Mundy GR, Inhibition of TGF-beta signaling by 1D11 antibody treatment increases bone mass and quality in vivo, Journal of Bone and Mineral Research, 25(11), 2419-2426, 2010.

Keller MD, Wilson RH, Mycek MA, Mahadevan-Jansen A, Monte Carlo model of spatially offset Raman spectroscopy for breast tumor margin analysis, Applied Spectroscopy, 64(6), 607-614, 2010.

Arrasmith CL, Dickensheets D, Mahadevan-Jansen A, MEMS-based handheld confocal microscope for in vivo skin imaging, Optics Express, 18(4), 3805-3819, 2010.

Keller MD, Majumder SK, Kelley MC, Meszoely IM, Boulos FI, Olivares GM, Mahadevan-Jansen A, Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast margin analysis, Lasers in Surgery and Medicine, 42(1), 15-23, 2010.

C. A. Patil, H. Krishnamoorthi, S. Munoz, G. Gutierrez, and A. Mahadevan-Jansen, “Rapid Measurement of Calvaria Volume and Biochemical Properties with Combined Raman Spectroscopy-Optical Coherence Tomography,” In preparation.


Virostko J, Jansen ED – Validation of bioluminescent imaging techniques – Methods in Molecular Biology 574: 15-23 (2009).

Keller MD, Kanter EM, Hutchings J, Kendal C, Stone N, Mahadevan-Jansen A, Spatial and temporal effects of cervical dysplasia as detected by Raman spectroscopy (invited paper), Disease Markers, 25(6), 323-337, 2009.

Duke AR, Cayce JM, Malphrus JD, Konrad P, Mahadevan-Jansen A,  Jansen ED – Combined optical and electrical stimulation of neural tissue in vivo – Journal of Biomedical Optics 14(6): 060501-3 (2009)

Granero-Moltó F, Weis JA, Miga MI, Landis B, Myers TJ, O'Rear L, Longobardi L, Jansen ED, Mortlock DP, Spagnoli A - Regenerative effects of transplanted mesenchymal stem cells in fracture healing - Stem Cells 27(8): 1887-98 (2009).

Kanter EM, Majumder SK, Kanter G, Woeste E, Mahadevan-Jansen A, Effect of hormonal variation on Raman spectra for cervical disease detection, American Journal of Obstetrics and Gynecology, 200(5), 512.e1, 2009.

Kanter EM, Majumder SK, Vargis E, Robichaux-Viehoever A, Kanter G, Shappell H, Jones III HW Mahadevan-Jansen A. Multi-class discrimination of cervical precancers using Raman spectroscopy, Journal of Raman Spectroscopy, 40(2), 205-211, 2009.

Keller, MD, Majumder SK, Mahadevan-Jansen A, Spatially offset Raman spectroscopy of layered soft tissues, Optics Letters, 34(7), 926-928, 2009

Kanter EM, Vargis E, Majumder SK, Keller MD, Kanter GJ, Rao GG, Mahadevan-Jansen A, Application of Raman spectroscopy for diagnosis of cervical dysplasia (invited paper), Journal of Biophotonics, 2(1-2), 81-90, 2009.

Zaman R, Rajaram N; Walsh A, Oliver J, Rylander H, Tunnell J, Welch A, Mahadevan-Jansen A,  Variation of fluorescence in tissue with temperature, Lasers in Surgery and Medicine, Suppl 21, 12-13, 2009.

Virostko J, Radhika A, Poffenberger G,Chen Z, Brissova M, Gilchrist J, Coleman B, Gannon M, Jansen ED, Powers AC - Bioluminescence imaging in mouse models quantifies β-cell mass in the pancreas and after islet transplantation – Mol Imaging and Biology, online: (doi:10.1007/s11307-009-0240-1), June (2009).

Cayce JM, Kao CC, Konrad PE, Jansen ED, Mahadevan-Jansen A, Optical stimulation of thalamocortical brain slices, Journal of Neuroscience (in review), February 2009.

Wilmink GJ, Oalenik SR, Beckham JT, Abraham AA, Nanney LB, Mahadevan-Jansen A, Davdson JM, Jansen ED, Molecular imaging-assisted optimization of HSP70 expression during laser-induced thermal preconditioning for wound repair enhancement, Journal of Investigative Dermatology, 129(1), 205-216, 2009.


Beckham JT, Wilmink GJ, Mackanos MA, Takahashi K, Contag CH, Takahashi T, Jansen ED – Role of hsp70 in cellular thermotolerance – Lasers Surg Med 40(10): 704-15 (2008).

Grimbergen M, van Swol CFP, van Moorselaar RJA, Mahadevan-Jansen A, Stone N, Effect of 5-ALA on the Raman spectra of bladder tissues, Journal of Photochemistry and Photobiology B (in press), December 2008.

Kanter EM, Vargis E, Majumder SK, Keller MD, Beaven RB, Rao GG, Mahadevan-Jansen A, Raman spectroscopy for cervical precancer detection. Gynecologic Oncology (in review), December 2008.

Keller MD, Kanter EM, Hutchings J, Kendal C, Stone N, Mahadevan-Jansen A, Spatial and temporal effects of cervical dysplasia as detected by Raman spectroscopy (invited paper), Disease Markers (in press), August 2008.

Lieber CA, Kanter EM, Mahadevan-Jansen A, Comparison of Raman spectrograph throughput using two commercial systems: transmissive versus reflective, Applied Spectroscopy, 62(5), 575-582, 2008.

Lieber CA, Majumder SK, Billheimer D, Ellis DL, Mahadevan-Jansen A, Raman microspectroscopy for skin cancer detection in vitro, Journal of Biomedical Optics, 13(2), epub: 024013, 2008.

Lieber CA, Majumder SK, Ellis DL, Billheimer D, Mahadevan-Jansen A, In vivo nonmelanoma skin cancer diagnosis using Raman microspectroscopy, Lasers in Surgery and Medicine, 40(7),461-467, 2008.

C. A. Patil, N. Bosschaart, M. D. Keller, T. G. van Leeuwen, and A. Mahadevan-Jansen, "Combined Raman spectroscopy and optical coherence tomography device for tissue characterization," Optics Letters, 33 (10), 1135-1137 (2008)

Wilmink GJ, Opalenik SR, Beckham JT, Mackanos MA, Nanney LB, Contag CH, Davidson JM, Jansen ED –In-vivo optical imaging of hsp70 expression to assess collateral tissue damage associated with infrared laser ablation of skin – J Biomed Opt 13, 054066 (2008)


Faley SL, Takahashi K, Crooke CE, Beckham JT, Tomemori T, Shappell SB, Jansen ED, Takahashi T - Bioluminescence imaging of vascular endothelial growth factor promoter activity in murine mammary tumorigenesis – In vivo bioluminescence imaging of VEGF promoter activity in transgenic mice – Mol Imaging 6(5):331-9 (2007)

Gebhart SC, Thompson RC, Mahadevan-Jansen A, Liquid-crystal tunable filter spectral imaging for brain tumor demarcation, Applied Optics, 46 (10): 1896-1910, 2007

Gebhart SC, Majumder SK, Mahadevan-Jansen A, Comparison of spectral variation from spectroscopy to spectral imaging, Applied Optics, 46 (8): 1343-1360, 2007.

Gorden DL, Fingleton B, Crawford HC, Jansen ED, Lepage M, Matrisian LM - Resident stromal cell-derived MMP-9 promotes the growth of colorectal metastases in the liver microenvironment – Intl J Cancer, April 6 (2007).

Izzo AD, Jansen ED, Richter CP, Walsh JT - Optical Parameter Variability in Laser Nerve Stimulation: a study of pulse duration, repetition rate, and wavelength – IEEE Transactions on Biomed Eng 54(6): (2007).

Lieber CA, Mahadevan-Jansen A, Development of a handheld Raman microspectrometer for clinical dermatologic applications, Optics Express, 15(19), 11874-11882, 2007.

Mackanos MA, Simanovskii D, Joos KM, Schwettman H, Jansen ED - Mid infrared optical parametric oscillator (OPO) as a viable alternative to tissue ablation with the free electron laser (FEL) – Lasers Surg Med 39(3): 230-6 (2007).

Majumder SK, Gebhart SC, Johnson MD, Thompson R, Lin WC, Mahadevan-Jansen A, A probability-based spectroscopic diagnostic algorithm for simultaneous discrimination of brain tumor and tumor margins from normal brain tissue, Applied Spectroscopy, 61 (5): 548-557, 2007 

Robichaux-Viehoever A, Kanter E, Shappell H, Billheimer D, Jones HW, Mahadevan-Jansen A, Characterization of Raman spectra measured in vivo for the detection of cervical dysplasia. Applied Spectroscopy, 61(9), 2007.

Toms SA, Lin WC, Weil R, Johnson MD, Jansen ED, Mahadevan-Jansen A - Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity – Neurosurgery 61(1): 327-35 (2007)

Virostko J, Powers AC, Jansen ED - Validation of luminescent source reconstruction using single-view spectrally resolved bioluminescence images – Appl Optics 46(13): 2540-7 (2007).

Wells JD, Kao C, Konrad P, Milner T, Kim J, Mahadevan-Jansen A, Jansen ED, Biophysical mechanisms of transient optical stimulation of peripheral nerve, Biophysical Journal 93(7), 567-80, 2007

Wells JD, Kao C, Jansen ED, Konrad PE, Mahadevan-Jansen A, Histological Analysis of thermal damage following transient optical neural stimulation, Laser in Surgery and Medicine, 39(6), 519-26, 2007.

Wells JD, Konrad PE, Kao CC, Jansen ED, Mahadevan-Jansen A - Pulsed laser versus electrical energy for peripheral nerve stimulation – J Neurosci Methods 163: 326-37 (2007).

Wells JD, Thomsen SL, Whittaker P, Jansen ED, Kao CC, Konrad PE, Mahadevan-Jansen A - Histological analysis reveals safety thresholds for optical nerve stimulation – Lasers Surg Med 39(6): 513-26 (2007)


Izzo AD, Richter CP, Jansen ED, Walsh JT - Laser Stimulation of the Auditory Nerve – Lasers Surg Med 38(7): 745-53 (2006).

Gebhart SC, Lin WC, Mahadevan-Jansen A, In vitro determination of normal and neoplastic human brain tissue optical properties using inverse adding-doubling, Physics in Medicine and Biology, 51 (8): 2011-2027, 2006.

Jansen ED, Pickett PM, Mackanos MA, Virostko JM - Effect of optical tissue clearing on spatial resolution and sensitivity of bioluminescence imaging – J Biomed Optics: 11:041119  (2006).

Jansen ED, Rastegar S – Pioneers in Biomedical Optics: Special Section Honoring Professor Ashley J. Welch, University of Texas at Austin, J Biomed Optics: 11: 041101 (2006).

Keller MD, Kanter EM, Mahadevan-Jansen A, Raman spectroscopy for cancer diagnosis, Spectroscopy (Cover), 21 (11): 33-41, 2006.

Moulton K, Lovell F, Williams E, Ryan P, Lay DC, Jansen ED, Willard S - Use of glycerol as an optical clearing agent for enhancing photonic transference and detection of Salmonella typhimurium through porcine skin – J Biomed Optics 11(5):05427 (2006).

Roth DJ, Jansen ED, Powers AC, Wang TG - A novel method of monitoring response to islet transplantation: bioluminescent imaging of an NF-kB transgenic mouse model – Transplantation 81(8): 1185-90 (2006).

Stevenson CB, Ehtesham M, Faley S, Cassady S, Jansen ED, Thompson RC – Development of quantum dot-based near-infrared molecular imaging for glioma – Neuro-Oncology 8(4): 489 (2006).

Virostko J, Jansen ED, Powers AC - Current status of imaging pancreatic islets - Current Diabetes Reports 6(4): 328–332 (2006).

Wells JD, Bendett M, Webb J, Ralph H, Kao C, Konrad PE, Mahadevan-Jansen A, Jansen ED, Lasers stimulate new techniques in nerve cells, International Biophotonics Journal (cover), Oct 2006.

Wilmink GJ, Opalenik SR, Beckham JT, Davidson JM, Jansen ED - Assessing laser-tissue damage with bioluminescent imaging – J Biomed Optics 11:041114 (2006). 


C.A. Patil, E.D. Jansen, “Novel Optical Technologies to Aid Diagnosis and Guide Therapy in Colorectal Medicine,” Seminars in Colon and Rectal Surgery, 16 (2), 82-90 (2005).

Fowler M, Virostko J, Chen Z, Smith SJ, West DB, Poffenberger G, Radhika A, Brissova M, Shiota M, Nicholson, Hirschberg B, Harlan D, Jansen ED, Powers AC – Assessment of pancreatic islet mass after transplantation using in vivo bioluminescence imaging – Transplantation 79(7): 768-76 (2005).

Gebhart SC, Jansen ED, Galloway RL - Dynamic, three-dimensional optical tracking of an ablative laser beam - Medical Physics 32(1): 209-20 (2005). 

Gebhart, SC, Mahadevan-Jansen A, Lin, WC, Experimental and simulated angular profiles of fluorescence and diffuse reflectance emission from turbid media, Applied Optics, 44(23), 4884-4901, 2005

Lin WC, Johnson M, Weil RJ, Mahadevan-Jansen A, Toms SA, In vivo optical spectroscopic detection of radiation injury in brain tissue, Neurosurgery, 57(3), 518-524, 2005

Mackanos MA, Kozub JA, Hachey DL, Joos KM, Ellis DL, Jansen ED – The effect of free electron laser pulse structure on mid-infrared soft-tissue ablation: biological effects – Physics in Medicine and Biology 50(8): 1885-99 (2005).

Mackanos MA, Kozub JA, Jansen ED – The effect of free electron laser pulse structure on mid-infrared soft-tissue ablation: ablation metrics – Physics in Medicine and Biology 50(8): 1871-83 (2005).

M.R. Chalita, Y. Li, S. Smith, C. Patil, V. Westphal, A.M. Rollins, J.A. Izatt, and D. Huang. “High-Speed Optical Coherence Tomography of Laser Iridotomy” American Journal of Ophthalmology, 140 (6), 1133-1136. 2005.

Teichman JM, Glickman RD, Chan KF, Jansen ED, Welch AJ - Plasma bubble formation induced by holmium laser – Urology 65(3): 627-8 (2005).

Toms SA, Lin WC, Weil RJ, Johnson MD, Jansen ED, Mahadevan-Jansen A - Intraoperative optical spectroscopy identifies infiltrating glioma margins with high sensitivity – Neurosurgery 57(4): 382-91 (2005).

Wells JD, Kao C, Jansen ED, Konrad PE, Mahadevan-Jansen A, Assessment of laser parameters for optical stimulation of peripheral nerves in vivo, Journal of Biomedical Optics, 10(6), 064003 (E-journal Locator), 2005.

Wells JD, Kao C, Mariappan K, Albea J, Jansen ED, Konrad P, Mahadevan-Jansen A -  Optical stimulation of neural tissue in vivo - Optics Letters 30(5): 504-6 (2005).


Anderson CD, Lin WC, Buttemere CR, Mahadevan-Jansen A, Phillips DJ, Pierce J, Nicoud I, Chari RS, Fluorescence spectroscopy accurately detects irreversible cell damage during hepatic radiofrequency ablation. Surgery, 136(3), 524-531, 2004

Anderson CD, Lin WC, Buttemere CR, Mahadevan-Jansen A, Phillips DJ, Pierce J, Nicoud I, Chari RS, Real-time spectroscopic assessment of thermal damage:  implications for radiofrequency ablation.  Journal of Gastrointestinal Surgery, 8(6), 660-669,2004.

Buttemere CR, Chari RS, Anderson CD, Mahadevan-Jansen A, Lin WC, “In vivo assessment of thermal damage in the liver using optical spectroscopy”, Journal of Biomedical Optics, 9(5), 1018-27, 2004

Beckham JT, Mackanos MA, Crooke C, Takahashi T, O’Conner-Rodwell CE, Contag CH, Jansen ED - Assessment of cellular response to thermal laser injury through bioluminescence imaging of hsp70 - Photochem Photobiol 79(1): 76-85 (2004). 

O’Connell-Rodwell CE, Shriver D, Simanovskii DM, McClure C, Cao Y, Zhang W, Bachmann MH, Beckham JT, Jansen ED, Palanker D, Schwettman HA, Contag CH - A genetic reporter of thermal stress defines physiologic zones over a defined temperature range – FASEB Journal 18:264-271 (2004). 

Powers AC, Jansen ED - In Vivo Bioluminescence Imaging to Assess Pancreatic Islets - Curr Med Chem 4(4): 339-48 (2004).

Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW - p47 (phox) deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia – J Immunology 172(3): 1801-8 (2004).

Virostko JM, Chen Z, Fowler M, Poffenberger G, Powers AC, Jansen ED - Factors influencing quantification of in vivo bioluminescence imaging: application to assessment of pancreatic islet transplants – J Mol Imaging 3(4): 333-42 (2004). 


Choi B, Jansen ED, Welch AJ – Acoustic-based measurements of material absorption coefficients: Relationship between laser pulse duration and stress confinement time – J Appl Phys 94(12): 7826-31 (2003).

Edwards GS, Austin RH, Carroll FE, Copeland ML, Couprie ME, Gabella WE, Haglund RF, Hooper BA, Hutson MS, Jansen ED, Joos KM, Kiehart DP, Lindau I, Miao J, Pratisto HS, Shen JH, Tokutake Y, van der Meer L, Xie A - FEL-based biophysical and biomedical instrumentation (invited review paper) – Rev Sci Instr 74(7): 3207-45 (2003)

Gray KD, Simovic MO, Chapman WC, Blackwell TS, Christman JW, Washington MK, Yull FE, Jaffal N, Jansen ED, Gautman S, Stain SC – Systemic NF-kappaB activation in a transgenic mouse model of acute pancreatitis – J Surg Res 110(1): 310-4 (2003)

Lieber CA, Mahadevan-Jansen A, “Automated Method for Subtraction of Fluorescence from Biological Raman Spectra”, Applied Spectroscopy, 57(11), 1363-1367, 2003

Lin WC, Buttermere C, Mahadevan-Jansen A, “Effect of thermal damage on the optical characteristics of liver tissues”, IEEE Journal of Selected Topics in Quantum Electronics, 9(2), 162-170, 2003.

Mackanos MA, Shaw BL, Aggarwal, ID, Katzir A, Jansen ED - Delivery of Mid-Infrared (6-7 um) Laser Radiation in a Liquid Environment Using Infrared-Transmitting Optical Fibers - J Biomed Optics 8(4): 583-93 (2003).

Sadikot RT, Han W, Everhart MB, Zoia O, Peebles RS, Jansen ED, Yull FE, Christman JW, Blackwell TS - Selective I-κB kinase expression in airway epithelium generates Neutrophilic lung inflammation - J Immunology 170(2): 1091-8 (2003).

Viehoever AR, Anderson D, Jansen ED, Mahadevan-Jansen A - Organotypic raft cultures as an effective tool for understanding Raman spectral analysis of tissue - Photochemistry & Photobiology 78(5): 517-24 (2003)

Wu NJ, Jansen ED, Davidson JM - Comparison of MMP-13 Expression In Free-Electron Laser and Scalpel Incisions During Wound Healing - J of Investigative Dermatology 21(4): 926-32 (2003).

Yull FE, Han W, Jansen ED, Sadikot RT, Christman JW, Blackwell TS – Bioluminescent detection of endotoxin effects on HIV-1 LTR driven transcription in vivo - Journal of Histochemistry and Cytochemistry 51(6): 741-749 (2003)


Chan KF, Choi B, Vargas G, Hammer DX, Sorg B, Pfefer TJ, Teichman JMH, Welch AJ, Jansen ED - Free electron laser ablation of urinary calculi: An experimental study - IEEE J Sp Top Quant Electr 7(6): 1022-33 (2002).

Lin WC, Toms SA, Jansen ED, Mahadevan-Jansen A – Intraoperative application of optical spectroscopy in the presence of blood, IEEE J Sp Top Quant Electr 7(6): 996-1003 (2002).

Sadikot RT, Wudel LJ, Jansen ED, Debelak JP, Yull FE, Christman JW, Blackwell TS, Chapman WC - Hepatic cryoablation-induced multisystem injury: bioluminescent detection of NF-kB activation in a transgenic mouse model - J Gastrointestinal Surg: 6: 264-270 (2002).

Wu N, Opalenik S, Liu J, Jansen ED, Giro MG, Davidson JM - Real-time visualization of MMP-13 promotor activity in transgenic mice - Matrix Biology 21:149-161 (2002).  


Lin WC, Toms SA, Jansen ED, Mahadevan-Jansen A, Intraoperative application of optical spectroscopy in the presence of blood, IEEE Journal of Selected Topics in Quantum Electronics 7(6), 996-1003, 2001.

Lin WC, Toms SA, Johnson M, Jansen ED, Mahadevan-Jansen, A - In Vivo Brain Tumor Demarcation Using Optical Spectroscopy - Photochemistry and Photobiology: 73(4): 396-402 (2001).

Izzo AD, Mackanos MA, Beckham JT, Jansen ED - In vivo optical imaging of expression of vascular endothelial growth factor following laser incision in skin - Lasers Surg Med: 29(4):343-350 (2001).

Sadikot RT, Jansen ED, Blackwell TR, Zoia, O, Yull FE, Christman JW, Blackwell TS - High dose dexamethasone accentuates NF-B activation in endotoxin-treated mice - Am J Respir Crit Care Med: 164:873-878 (2001).

Utzinger U, Mahadevan-Jansen A, Hinzelman D, Follen M, Richards-Kortum R. Near infrared Raman spectroscopy for in vivo detection of cervical precancers, Applied Spectroscopy, 55(8), 2001


Chan KF, Hammer DX, Choi B, Teichman JM, McGuff HS, Pratisto HS, Jansen ED, Welch AJ - Free Electron Laser lithotripsy: Threshold radiant exposures - Journal of EndoUrology 14(2):161-7 (2000).

Lin WC, Toms SA, Motamedi M, Jansen ED, Mahadevan-Jansen A - Brain  tumor demarcation using optical spectroscopy: an in vitro study - J Biomedical Optics 5(2): 214-220 (2000).

Pratisto HS, Uhlhorn SR, Jansen ED - Beam delivery of the Vanderbilt Free Electron Laser with hollow wave guides: effect on temporal and spatial pulse propagation - Fiber and Integrated Optics: 20(1): 83-94 (2000).

Ramanujam N, Richards-Kortum R, Thomsen S, Mahadevan-Jansen A, Follen M, Chance B, Low temperature fluorescence imaging of freeze-trapped human cervical tissues, Optics Express, 8(6), 335-343, December 2000.


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